10. In step 3 of the citric acid cycle, the enzyme isocitrate dehydrogenase is regulated by NADH. Compare and contrast the regulation of this enzyme with the regulation of phosphofructokinase in glycolysis.

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 10. In step 3 of the citric acid cycle, the enzyme isocitrate dehydrogenase is regulated by NADH. Compare and contrast the regulation of this enzyme with the regulation of phosphofructokinase in glycolysis.

answer:

Both phosphofructokinase and isocitrate dehydrogenase are regulated by feedback inhibition, where the product of the reaction or series of reactions inhibits the enzyme activity. They differ in that phosphofructokinase is regulated by allosteric inhibition while isocitrate dehydrogenase is controlled by competitive inhibition.

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